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Ion suppression

Seen on mass-spectrometric limitation statements.

Definition

Reduction of an analyte signal caused by co-eluting material competing for charge during ionisation. It can depress or entirely remove a real signal, which is why an absent signal is not by itself evidence of absent material.

Related terms

Matrix effect
The influence everything other than the analyte has on the measurement: suppressing ionisation, interfering with detection, or reducing recovery.
Co-elution
Two or more components leaving the column at the same time and integrating as a single peak.

About mass spectrometry

Terms a reader meets on mass-spectrometric reports from other laboratories, and on confirmatory work sent out. This laboratory has no in-house mass spectrometer, and its certificates carry no mass spectrum.

Electrospray ionisationMass-to-charge ratioCharge stateDeconvolutionObserved massTheoretical massMass accuracyIsotope patternIsobaricStereoisomerRetro-inverso peptide

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